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【报告通知】第三十九期“青年学者论坛”—高宁教授报告会
发布人:高雪  发布时间:2019-03-04   浏览次数:10

应我校“青年学者论坛”邀请,教育部2017年度“长江学者奖励计划”特聘教授、北京大学生命科学学院副院长、膜生物学国家重点实验室副主任—高宁教授于3月5日来访我校,访问期间将举办学术报告进行交流,欢迎广大师生参加。

报告题目:Structural  Insights into the DNA Replication Initiation  in Budding Yeast

人:高宁教授

报告时间35日  上午900

报告地点:明德楼 B305

主办单位:人事处

承办单位:澳门赌博游戏平台网址/生命科学中心

报告人简介

高宁,北京大学生命科学学院教授、副院长,膜生物学国家重点实验室副主任。受聘为教育部2017年度“长江学者奖励计划”特聘教授。主要运用冷冻电镜技术研究多种与重大生命过程相关的核酸蛋白质复合物的结构和功能,在Nature、CellNSMBMol  Cell等杂志发表论文40余篇,这些工作阐释了核糖体在细胞内组装的分子途径、组装因子的功能及机制、新型核糖体结合因子调控蛋白质合成的多种工作模式,以及阐明了DNA复制起始过程的关键分子机器ORC、MCM如何组装及识别DNA复制起点序列的分子机制。获得国家杰出青年科学基金的资助,还获得了谈家桢生命科学奖、中源协和生命医学创新突破奖、药明康德生命化学奖、茅以升北京青年科技奖等奖励。

报告摘要:

Each  cell division requires one and only one cycle of exact DNA replication to ensure  each daughter cells inherit one complete suite of genome. Aberrant DNA  replication induces genome instability, which is the hallmark of many cancers.  ORC, a complex composed of six subunits, Orc1 to Orc6, is used to mark the  replication initiation sites in all eukaryotes. The abnormal selection of origin  sites may lead to severe development disorders. Meier-Gorlin syndrome (MGS) is a  rare autosomal recessive hereditary dwarfism disorder, characterized by an  intrauterine growth retardation and a postnatal slow-growth rate. Interesting,  most mutations detected in patients with MGS are located on one of the five  genes, ORC1, ORC4, ORC6, CDT1, and CDC6, all of which are involved in  replication initiation, especially in origin selection. However, the details of  molecular mechanisms for its specific recognition to origin DNA sequence is  still unknown. High-resolution structures could provide a lot of information to  understand the functional mechanism of the molecular machine. Our structural  study serves as a structural framework for understanding how ORC recognizes and  binds yeast origin DNA, and also provides insight into the helicase loading  mechanism in metazoans.